Diagnostic performance evaluation of the Siemens Healthineers Atellica HEMA 580 hematology analyzer for abnormal cell detection and optimization of immature myeloid cell cut-offs

The Atellica HEMA 580 provided reliable performance in detecting immature myeloid cells and NRBCs. The IMG cut-off >0.8, determined through ROC optimization, supports its implementation for enhancing laboratory workflow efficiency while maintaining diagnostic accuracy. These findings support the clinical implementation of the Atellica HEMA 580 for routine hematology laboratories, particularly for enhanced detection of clinically significant immature myeloid populations.