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March 4, 2026PEDIATRICS

Epidemiology of Herpes Simplex Virus in Infants Aged 0–42 Days: 2008–2024

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Authors

TGTara L. GreenhowKaiser PermanenteZSZahra Samiezade-YazdTwitter (United States)LBLea BornsteinKaiser Permanente

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Implication

A retrospective study reports trends in herpes simplex virus incidence in infants, highlighting post-pandemic changes.

Key Points

  • To report the trends and incidence of herpes simplex virus (HSV) disease in infants aged 0-42 days from 2008 to 2024.
  • Performed a retrospective analysis of infants with HSV disease born between 2008 and 2024.
  • Captured data on demographics, clinical symptoms, and HSV subtype.
  • Analyzed trends in overall HSV disease and specific disease types over time.
  • Identified 62 cases of HSV disease among 632,979 infants with a cumulative incidence of 9.8 per 100,000 births.
  • Cumulative incidence for skin, eye, and/or mouth disease was 5.4, disseminated disease was 2.8, and central nervous system disease was 1.6 per 100,000 births.
  • Notable increase in disseminated disease incidence was observed between 2021 and 2024, rising by 4.5 per 100,000 births per year.

Cite This Study

Greenhow et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd1dd48f933b5eed9355https://doi.org/10.1542/peds.2025-073629
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