Value of LDH/ALB ratio in prediction of short-term mortality in patients with severe burns

The predictive value of Lactate dehydrogenase (LDH)/ Albumin (ALB) ratio (LAR) in patients with severe burns has not been explored. The aim of the study was to investigate the correlation between LAR at admission and short-term mortality in severe burned patients. Patients with a primary diagnosis of severe burns, defined as 30% Total Body Surface Area (TBSA) or more, admitted to the burn center of Changhai Hospital were screened, and 324 patients were ultimately enrolled in this study. Binary logistic regression, univariate and multivariate analyses, Least Absolute Shrinkage and Selection Operator (LASSO) regression, Receiver Operating Characteristic (ROC) analysis, Kaplan-Meier curve and nomogram were used to analyze and present the relationship between admission LAR and short-term mortality. Patients with high admission LAR were more likely to die than low LAR. Age, LAR, TBSA, tracheostomy and heart disease were used to establish the nomogram with LAR having the highest area under the curve (AUC) value. We utilized nomograms to visually express data analysis results. This nomogram incorporates the lymphocyte-to-albumin ratio (LAR), a robust and readily accessible prognostic marker, to aid in the identification of patients with severe burns who are at high risk for short-term mortality. Therefore, it is well-suited for early risk stratification, from initial patient assessment after admission to the early inpatient phase, particularly in mass-casualty incidents like forest fires and explosions.