Real-World Utilization Pattern and Outcomes of Letermovir in Adult Cytomegalovirus-Seropositive Allogeneic Hematopoietic Cell Transplant Recipients: An International Retrospective Study From the Infectious Diseases Working Party of EBMT.

Q: What does this research mean for the field?

Letermovir prophylaxis in adult CMV-seropositive allogeneic hematopoietic cell transplant recipients is associated with a low incidence of clinically significant cytomegalovirus infection compared to previously published data. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Iwona Żak; Gloria Tridello; Nina Knelange; Lotus Wendel; Per Ljungman; Dina Averbuch; Domenico Russo; A. Xhaard; Alida Dominietto; Francesco Onida; David Beauvais; Emma Kempshall; Ilaria Cutini; Patrizia Chiusolo; Uwe Platzbecker; Angelo Michele Carella; Annie Ferreri; Maria Catarina Mico; Sabrina Kraus; Varun Mehra; Leotta Salvatore; Vincenzo Federico; Yuexin Tang; Irina Kolobova; A Beyer; Deepa Patel; Salut Brunet

doi:10.1111/tid.70196

Key Points

To assess the real-world utilization and outcomes of letermovir in preventing CMV in allogeneic hematopoietic cell transplant recipients.
Conducted an international retrospective study
Analyzed CMV infection rates post-allo-HCT
Evaluated letermovir usage patterns among recipients
Observed low incidence of cytomegalovirus infections compared to previous reports
Demonstrated effectiveness of letermovir in real-world settings
Provided insights into management of CMV prophylaxis in transplant recipients

Implication

An international retrospective analysis shows reduced cases of cytomegalovirus infection in allogeneic transplant recipients using letermovir.

Abstract

An analysis of real-world use of letermovir in CMV prophylaxis after allo-HCT showed a low incidence of csCMVi compared to previously published information.

Discussion

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Cite This Study

Żak et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd7ed48f933b5eed9d74 https://doi.org/10.1111/tid.70196

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Real-World Utilization Pattern and Outcomes of Letermovir in Adult Cytomegalovirus-Seropositive Allogeneic Hematopoietic Cell Transplant Recipients: An International Retrospective Study From the Infectious Diseases Working Party of EBMT.

Key Points

Implication

Abstract

Discussion

Cite This Study

Real-World Utilization Pattern and Outcomes of Letermovir in Adult Cytomegalovirus-Seropositive Allogeneic Hematopoietic Cell Transplant Recipients: An International Retrospective Study From the Infectious Diseases Working Party of EBMT.

Key Points

Implication

Abstract

Discussion

Cite This Study

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