Why the study?
Does ablation of frequent PVCs reduce mortality and morbidity in patients with left ventricular systolic dysfunction?
Does ablation of frequent PVCs reduce mortality and morbidity in patients with left ventricular systolic dysfunction?
In patients with LV systolic dysfunction, successful ablation of frequent PVCs is associated with sustained structural improvements and a lower risk of hard clinical heart failure endpoints.
May lower hard HF endpoints after PVC ablation in LV systolic dysfunction; hypothesis-generating and requires RCTs to confirm.
In patients with LV systolic dysfunction, ablation of frequent PVCs induces a significant improvement in functional, structural, and neurohormonal status, which persists at LTFUP. A sustained reduction in the baseline PVC burden is associated with a lower risk of cardiac mortality, cardiac transplantation, or hospitalization for heart failure during follow-up.
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Berruezo et al. (2019) studied this question.
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