Successful sustained ablation of frequent PVCs in patients with depressed LVEF increased LVEF from 33.7% to 45.8% at 12 months (p<0.05), independent of structural heart disease status.
Cohort (n=80)
Yes
Does PVC ablation improve LVEF, BNP, and NYHA class in patients with frequent PVCs and depressed LVEF, regardless of underlying structural heart disease?
Successful ablation of frequent PVCs in patients with depressed LVEF significantly improves LVEF, BNP, and NYHA class, regardless of the presence of underlying structural heart disease.
p-value: p=<0.05
OBJECTIVES: This study aimed to assess the benefit after ablation of premature ventricular complexes (PVC) in patients with frequent PVC and left ventricular (LV) dysfunction, regardless of previous structural heart disease (SHD) diagnosis, PVC morphology, or estimated site of origin. BACKGROUND: Ablation of PVC in patients with LV dysfunction is usually restricted to patients with suspected PVC-induced cardiomyopathy. METHODS: Consecutive patients with frequent PVC and LV dysfunction accepted for ablation at 4 centers were prospectively included. Of the 80 patients included, 27 (34%) had a diagnosis of SHD. RESULTS: Successful sustained ablation (SSA) was achieved in 53 (66%) patients, and LVEF improved in these patients from 33.7 ± 8% to 43.8 ± 9.4% and 45.8 ± 10.9% at 6 and 12 months, respectively (p 13% PVC and SSA had class I indication for cardioverter defibrillator implantation, these indications were absent at 6 months post-ablation. CONCLUSIONS: Independently of the presence of SHD, the SSA of frequent PVC in patients with depressed LVEF induced a progressive clinical and functional improvement. Improvement in heart failure parameters was related to baseline PVC burden and persistence of ablation success.
“If you have a patient with frequent premature ventricular complex and primary prevention ICD indication you must first ablate, withhold the ICD implant and re-evaluate the implantation during the first to sixth month post ablation. This seems to be an appropriate and safe strategy.”
Penela et al. (Wed,) conducted a cohort in Frequent premature ventricular complexes and left ventricular dysfunction (n=80). Premature ventricular complex ablation was evaluated on Left ventricular ejection fraction (LVEF) at 12 months (p=<0.05). Successful sustained ablation of frequent PVCs in patients with depressed LVEF increased LVEF from 33.7% to 45.8% at 12 months (p<0.05), independent of structural heart disease status.