In adults with severe metabolic acidosis and moderate to severe AKI, IV sodium bicarbonate did not reduce mortality at 90 d

Key Points

• To investigate whether intravenous sodium bicarbonate reduces mortality in adults with severe metabolic acidosis and acute kidney injury.
• Adults with severe metabolic acidosis and moderate to severe acute kidney injury were treated with IV sodium bicarbonate.
• Mortality rates were assessed at 90 days post-treatment.
• IV sodium bicarbonate treatment did not demonstrate a significant reduction in mortality at 90 days.
• No differences in outcomes were observed between treatment and control groups.