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March 5, 2026CureusOpen Access

Evaluating Clinical Outcomes in Children With Acute Osteomyelitis Treated With Intravenous Versus Oral Antimicrobial Therapy

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Authors

TWTiffany WithrowHLHannah LuADAnkita Desai

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Overview

Retrospective chart review evaluates outcome differences of IV and oral antibiotic treatment in children, suggesting oral therapy may be safer.

Key Points

  • This research aims to compare the efficacy and safety of intravenous versus oral antibiotic therapy for osteomyelitis in children.
  • Retrospective chart review of patients under 18 with acute osteomyelitis from January 2019 to December 2021.
  • Patients categorized by antibiotic route at discharge (IV or PO).
  • Comparison of treatment failure rates and adverse drug events between the two groups.
  • Fifty-one patients were evaluated: 19 in the oral group and 32 in the intravenous group.
  • No significant difference in treatment failure rates (IV: 9.4%, PO: 10.5%; p=1.000).
  • Higher rates of adverse drug events were observed in the IV group compared to the PO group.

Cite This Study

Withrow et al. (2026) studied this question.

synapsesocial.com/papers/69a91cbed6127c7a504bfb4fhttps://doi.org/10.7759/cureus.104551
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Opportunities for Stewardship in the Transition From Intravenous to Enteral Antibiotics in Hospitalized Pediatric Patients2021 · 18 citations
  2. 2Oral Antibiotics Are Effective for the Treatment of Hand Osteomyelitis in Children2018 · 13 citations
  3. 3Antibiotic-Associated Adverse Events in Hospitalized Children2020 · 53 citations
  4. 4Adverse Events in Pediatric Patients Receiving Long-term Oral and Intravenous Antibiotics2016 · 27 citations
  5. 5Oral versus Intravenous Antibiotics for Bone and Joint Infection2019 · 942 citations