Key result
Prediabetes linked to ~14% higher incident CVD risk regardless of diagnostic criteria.
Why the study?
Does prediabetes defined by ADA or WHO/IEC criteria increase the risk of incident cardiovascular disease and mortality compared to normoglycemia in individuals without baseline cardiovascular disease?
Observational (n=278,697)
Does prediabetes defined by ADA or WHO/IEC criteria increase the risk of incident cardiovascular disease and mortality compared to normoglycemia in individuals without baseline cardiovascular disease?
Hazard Ratio: 1.14 (95% CI 1.12–1.16)
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Prediabetes, regardless of whether defined by ADA or WHO/IEC criteria, is causally associated with an increased risk of incident cardiovascular disease and mortality, with WHO/IEC criteria identifying a higher-risk cohort.
Zheng et al. (2026) conducted an observational in Prediabetes (n=278,697). Prediabetes vs. Normoglycemia was evaluated on Incident cardiovascular disease (CVD) (HR 1.14, 95% CI 1.12-1.16). Prediabetes elevated the risk of incident cardiovascular disease over 13.5 years regardless of diagnostic criteria (ADA: HR 1.14, 95% CI 1.12-1.16; WHO/IEC: HR 1.23, 95% CI 1.19-1.27).
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