Why the study?
The impact of prediabetes identified by different glycemic thresholds (ADA vs WHO/IEC criteria) and diagnostic tests (FPG vs HbA1c) on clinical outcomes in patients with stable CAD was unclear.
Does prediabetes defined by WHO/IEC criteria versus ADA criteria predict major adverse cardiovascular events in patients with stable coronary artery disease?
Population
4088 stable CAD non-diabetic patients
Comparison
ADA-defined vs WHO/IEC-defined prediabetes vs normoglycaemia
Design
Prospective cohort study
Follow-up
Median 3.2 years
Authors
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WHO/IEC-defined prediabetes was associated with higher MACE risk in stable CAD; leaves open whether stricter thresholds warrant clinical adoption pending trials.
Does prediabetes defined by WHO/IEC criteria versus ADA criteria predict major adverse cardiovascular events in patients with stable coronary artery disease?
In patients with stable coronary artery disease, WHO/IEC criteria for prediabetes (driven by HbA1c) better predict major adverse cardiovascular events than ADA criteria.
Cui et al. (2023) studied this question.
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