Three components synthesis of tetracyclic fused Scafold of Pyrazolopyrimidobenzosultam derivatives

Key Points

• This research aims to develop an effective method for synthesizing pyrazolopyrimidobenzosultam derivatives using a three-component reaction.
• Utilized a three-component one-pot reaction involving N-methyl 1,2-benzothiazinone 1,1-dioxide, benzaldehyde, and 5-amino pyrazole.
• Conducted the reaction using KOH as a base.
• Avoided the use of heavy metals in the synthesis.
• Successfully synthesized a new heterocyclic structure.
• Achieved positive yields in the synthesis process.
• Incorporated pyrazole, dihydropyridine, and sultam scaffolds through Michael addition, cyclisation, and condensation.