What does this research mean for the field?

A copper-catalyzed one-pot three-component reaction followed by reaction with a sulfinate salt provides a rapid and efficient two-step method for synthesizing diverse tricyclic-benzazoles containing a sulfonyl scaffold. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop a simple, mild, and efficient synthetic strategy to access diverse tricyclic-benzazole derivatives functionalized with a sulfonyl scaffold.

August 16, 2026Journal of Sulfur Chemistry

A simple and effective approach to the synthesis of new diverse tricyclic-benzazoles containing a sulfonyl scaffold

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Authors

MNManijeh NematpourFarhangian University

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Implication

Experimental study demonstrates a copper-catalyzed two-step synthesis of functionalized tricyclic-benzazoles with sulfonyl groups, providing a rapid route to diverse fused heterocycles.

Key Points

Develop a simple, mild, and efficient synthetic strategy to access diverse tricyclic-benzazole derivatives functionalized with a sulfonyl scaffold.
Employed a copper-catalyzed one-pot, three-component reaction coupling terminal alkynes, trichloroacetonitrile, and benzazoles (benzothiazole, benzoxazole, or benzimidazole).
Conducted a subsequent nucleophilic substitution replacing the trichloromethyl leaving group with sulfinate salts in tetrahydrofuran at room temperature.
Directly constructed tricyclic-benzazole intermediates under mild conditions with moderate to good yields.
Successfully synthesized 15 novel tricyclic-benzazole derivatives containing sulfonyl scaffolds via this two-step protocol.

Cite This Study

Manijeh Nematpour (2026) studied this question.

synapsesocial.com/papers/6a817a01f2fb91fc834ad934 https://doi.org/10.1080/17415993.2026.2716187

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Implication

Experimental study demonstrates a copper-catalyzed two-step synthesis of functionalized tricyclic-benzazoles with sulfonyl groups, providing a rapid route to diverse fused heterocycles.

A simple and effective approach to the synthesis of new diverse tricyclic-benzazoles containing a sulfonyl scaffold

Discussion

Member takes

Implication

Key Points

Cite This Study

A simple and effective approach to the synthesis of new diverse tricyclic-benzazoles containing a sulfonyl scaffold

Discussion

Member takes

Implication

Key Points

Cite This Study

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