Exploring an Efficient Pathway to Access Diversely Substituted Benzothiazole Derivatives through Heterogeneous Catalysis

An expeditious and highly efficient methodology for synthesizing diversely substituted benzothiazole derivatives 3a–3j is reported. This approach involves the condensation of various substituted aldehydes with 2-aminobanzenethiol in the presence of the copper silicate catalyst (15 mol %) in ethanol under reflux conditions. The present protocol offers several notable advantages, including good to excellent yields, short reaction times, and an easy workup procedure. These attributes collectively enhance the feasibility, cost-effectiveness, and environmental sustainability of the synthetic route. The use of an inexpensive and eco-friendly catalyst is the key feature of this process. The synthesized products were characterized by spectral techniques such as 1H and 13C NMR, IR, and mass spectroscopy.