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This review aims to clarify the genetic connections among psychiatric disorders, metabolic syndrome, and antipsychotic medications.

March 5, 2026Schizophrenia ResearchOpen Access

Disentangling the relationship between psychiatric disorders, cardiometabolic abnormalities, and antipsychotics: A systematic review of genomic studies

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This review aims to clarify the genetic connections among psychiatric disorders, metabolic syndrome, and antipsychotic medications.
Conducted systematic searches in PubMed, Scopus, and Web of Science for relevant studies.
Included studies published between January 2005 and August 2025, totaling seventy-seven.
Analyzed genomic studies focusing on psychiatric disorders and metabolic traits.
Identified substantial shared genetic architecture between psychiatric disorders and metabolic traits.
Reported causal relationships showing MDD's unidirectional effect on MetS and bidirectional effects between SCZ and BMI.
Demonstrated that antipsychotic-induced weight gain has a specific genetic basis.

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Systematic review evaluates genetic links between psychiatric disorders, metabolism, and antipsychotic use, suggesting clinical implications.

Shepherd et al. (2026) studied this question.

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Systematic review evaluates genetic links between psychiatric disorders, metabolism, and antipsychotic use, suggesting clinical implications.