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March 5, 2026Clinical Kidney JournalOpen Access

Impact of Raas-Blockers on Serum Potassium And Mortality in a Large Dialysis Cohort: A Longitudinal Analysis

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Authors

VCVincenzo CalabreseGTGiovanni TripepiDSDomenico Santoro

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Overview

Longitudinal analysis evaluates RAASIs effects on potassium levels and mortality in dialysis patients, suggesting reevaluation of their use.

Key Points

  • This research evaluates the effects of RAAS inhibitors on serum potassium and mortality among dialysis patients.
  • Included 4764 dialysis patients from the Sicilian Registry of Nephrology, Dialysis, and Transplantation.
  • Analyzed the relationship between RAASIs intake and serum potassium using linear mixed models.
  • Assessed mortality using univariate and multivariate Cox models.
  • 25% of patients were treated with RAAS inhibitors.
  • RAASIs intake was associated with increased serum potassium levels (adjβ = 0.10, p < 0.001).
  • No association was found between RAASIs intake and mortality (adjHR = 0.76, p = 0.31).

Cite This Study

Calabrese et al. (2026) studied this question.

synapsesocial.com/papers/69a91dedd6127c7a504c1438https://doi.org/10.1093/ckj/sfag025
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