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March 5, 2026Clinical Infectious Diseases2 citations

Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium abscessus : Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study

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KWKevin L WinthropPFPatrick A. FlumeRKReeti Khare

Key Points

  • This research aims to evaluate the effectiveness of omadacycline monotherapy in treating nontuberculous mycobacterial pulmonary disease caused by M. abscessus.
  • Conducted a phase 2, double-blind, randomized, placebo-controlled trial
  • Compared omadacycline monotherapy to placebo
  • Evaluated multiple treatment endpoints
  • Omadacycline monotherapy consistently favored over placebo across several endpoints
  • Treatment was well tolerated with nausea being the most frequent side effect
  • Further investigations into omadacycline's efficacy are suggested

Abstract

Results consistently favored omadacycline monotherapy over placebo across several endpoints in NTM-PD caused by M. abscessus. Omadacycline was well tolerated; nausea was the most frequent TEAE. Further investigations are warranted.

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Cite This Study

Winthrop et al. (2026) studied this question.

synapsesocial.com/papers/69a91e1fd6127c7a504c1c86https://doi.org/10.1093/cid/ciag062
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacies of three drug regimens containing omadacycline to treat Mycobacteroides abscessus disease2024 · 11 citations
  2. 2Efficacies of omadacycline + amikacin + imipenem and an all-oral regimen omadacycline + clofazimine + linezolid in a mouse model of M. abscessus lung disease2024 · 7 citations
  3. 3Mycobacterium abscessus . “Pleased to Meet You, Hope You Guess My Name..”2015 · 102 citations
  4. 4The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance2018 · 267 citations
  5. 5Outcomes in patients with Mycobacterium abscessus pulmonary disease treated with long-term injectable drugs2011 · 114 citations