Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2023Open Forum Infectious DiseasesOpen Access

Eradicating Pulmonary Mycobacterium abscessus : The Promise of Dual β-Lactam Therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

BABayan AlahmdiKDKhalid M DousaSKSebastian G. Kurz

Discussion

Loading...

Member takes

Overview

Case report demonstrates successful cure of pulmonary Mycobacterium abscessus with dual beta-lactams, highlighting a viable strategy against resistant strains.

Key Points

  • To assess the therapeutic potential of a dual β-lactam combination regimen in treating a patient with macrolide-resistant Mycobacterium abscessus infection.
  • Administered a multidrug regimen incorporating dual β-lactam antibiotics to a single patient with pulmonary Mycobacterium abscessus infection.
  • Dual β-lactam therapy as part of a multidrug regimen achieved complete clinical cure of the Mycobacterium abscessus infection.
  • The clinical response corroborated prior in vitro findings showing potent synergy of dual β-lactam combinations against macrolide-resistant isolates.

Cite This Study

Alahmdi et al. (2023) studied this question.

synapsesocial.com/papers/6a8b008dc716e89f35dece3ehttps://doi.org/10.1093/ofid/ofad312
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline2020 · 948 citations
  2. 2Insights into the l , d -Transpeptidases and d , d -Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors2020 · 60 citations
  3. 3Rapid detection of mutations in erm(41) and rrl associated with clarithromycin resistance in Mycobacterium abscessus complex by denaturing gradient gel electrophoresis2017 · 17 citations
  4. 4Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action2022 · 46 citations
  5. 5Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro2019 · 79 citations