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March 5, 2026Analytical Chemistry

Evaluation of Intermolecular Interactions in HPLC Using Deuterated Mobile Phases

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Authors

KAKosuke AmanoEKEisuke KanaoSKSayaka K.-Yamada

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Overview

Study evaluates solvent deuteration effects on intermolecular interactions in HPLC, suggesting systematic alterations.

Key Points

  • This study aims to investigate how deuterated solvents influence solute-solvent and solute-stationary phase interactions in HPLC.
  • Applied deuterated solvents as mobile phases in HPLC
  • Compared retention behavior of analytes with hydrogenated solvents
  • Examined both reversed-phase and normal-phase HPLC setups
  • Deuterated solvents increased retention of all analytes in reversed-phase HPLC
  • Indicated reduced affinity between deuterated solvents and hydrophobic compounds
  • Weakened CH-π and OH-π interactions particularly affected aromatic analytes
  • π-π interactions showed minimal sensitivity to solvent deuteration

Cite This Study

Amano et al. (2026) studied this question.

synapsesocial.com/papers/69a91e57d6127c7a504c231ahttps://doi.org/10.1021/acs.analchem.5c07328
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