Yang et al. demonstrate that tetraploid embryos adjust their biology to thrive, indicating evolutionary adaptability.
Yang et al. show that C. elegans embryos adapt to tetraploidy and maintain viability by scaling their transcriptome proportionately to their increased cell volume. Tetraploids display slower cell cycles and prolonged embryogenesis due to an elevated DNA-cell volume ratio.
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Lessenger et al. (2026) studied this question.
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