Key result
Low BMI linked to ~10% higher all-cause mortality in older adults with T2DM.
Why the study?
The study investigated the association between low BMI and core lipid parameters with all-cause mortality in older adults with T2DM, including the mediating roles of cholesterol parameters.
Does low BMI (< 22 kg/m2) increase all-cause mortality in older adults with T2DM, and do cholesterol parameters mediate this risk?
Cohort (n=372,559)
Yes
Does low BMI (< 22 kg/m2) increase all-cause mortality in older adults with T2DM, and do cholesterol parameters mediate this risk?
Effect estimate: HR 1.10 (95% CI 1.06-1.13)
p-value: p=<0.001
Low BMI (< 22 kg/m2) is independently associated with increased all-cause mortality in older adults with T2DM, a relationship partially masked by negative mediation through reduced cholesterol parameters, particularly HDL-C.
May warrant nutritional intervention in low-BMI older T2DM adults; extends understanding of negative HDL-C mediation yet remains hypothesis-generating.
The present study aims to investigate the association of low body mass index (BMI < 22 kg/m2) and core lipid parameters on all-cause mortality among older adults with type 2 diabetes mellitus (T2DM), and to assess the mediating roles of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Data were analyzed from 372,559 T2DM participants aged ≥ 60 years, obtained from the Shanghai Center for Disease Control and Prevention (SCDC) diabetes management cohort, stratified by BMI < 22 kg/m2. Associations between low BMI and lipid parameters were examined using linear regression, associations of low BMI and lipid parameters with mortality risk were assessed via Cox regression. Restricted cubic spline (RCS) models were used to evaluate nonlinear trends, and Bayesian mediation models quantified the mediating effects. The low BMI group had a significantly higher risk of all-cause mortality compared to the non-low BMI group (HR = 1.10, 95% CI: 1.06 ~ 1.13). Among the lipid parameters, TC, HDL-C, and LDL-C were nonlinearly associated with mortality risk (U-shaped for TC and LDL-C, L-shaped for HDL-C), with optimal thresholds identified at 5.03 mmol/L, 0.98 mmol/L, and 3.39 mmol/L, respectively. Mediation analysis demonstrated significant negative mediation for TC (proportion mediated, PE = –16.68%), HDL-C (PE = –111.99%), and LDL-C (PE = –4.12%), with HDL-C showing the strongest masking effect (βACME = 1.44, 95% CI: 1.33 ~ 1.56). Low BMI is independently associated with an increased risk of mortality in T2DM older adults. Cholesterol parameters, particularly HDL-C, may explain part of this association through negative mediation. These findings suggest the need for clinical attention to lipid metabolic disturbances among underweight older adults.
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Mo et al. (2026) conducted a cohort in Older adults (≥60 years) with type 2 diabetes mellitus (T2DM) (n=372,559). Low BMI (body mass index <22 kg/m²) vs. Non-low BMI (body mass index ≥22 kg/m²) was evaluated on All-cause mortality (HR 1.10, 95% CI 1.06-1.13, p=<0.001). Low BMI (<22 kg/m²) increased all-cause mortality risk by 10% (HR 1.10, 95% CI 1.06–1.13) compared to BMI ≥22 in older adults with T2DM over median 19 months.
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