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March 6, 2026Journal of Affective DisordersOpen Access

Unstable sleep and rest-activity rhythms in adolescents at-risk for bipolar disorder: Links to mood symptoms and the effect of sleep stabilization

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Authors

JSJoao Paulo Lima SantosUniversity of Pittsburgh LKLauren KellerUniversity of Pittsburgh AHAmy G. HartmanUniversity of Pittsburgh

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Implication

Actigraphy reveals links between sleep instability and mood symptoms in adolescents at-risk for bipolar disorder, suggesting sleep stabilization may help.

Key Points

This research aims to investigate the relationship between sleep instability and mood symptoms in adolescents with a parental history of bipolar disorder.
Conducted a study with 50 adolescents stratified into High-Risk and Low-Risk groups based on parental bipolar disorder history.
Monitored sleep patterns using actigraphy over a two-week baseline period.
Applied a two-week sleep stabilization protocol for High-Risk participants targeting regular sleep timing and duration.
Collected mood symptom data using depression and mania rating scales at baseline and post-manipulation.
Analyzed between-group differences in sleep characteristics and their associations with mood symptoms.
No significant between-group differences in sleep and rest-activity rhythms were found.
Increased sleep duration variability in High-Risk adolescents correlated with higher depressive and mania symptoms.
Lower Circadian Function Index was linked to increased mania symptoms specifically in the High-Risk group.
Sleep stabilization reduced sleep duration and midsleep variability and improved Circadian Function Index.
Trend-level reductions in subthreshold mania symptoms were observed following the intervention.

Cite This Study

Santos et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f3c531e4c4a9ff594ba https://doi.org/10.1016/j.jad.2026.121558

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Implication

Actigraphy reveals links between sleep instability and mood symptoms in adolescents at-risk for bipolar disorder, suggesting sleep stabilization may help.

Unstable sleep and rest-activity rhythms in adolescents at-risk for bipolar disorder: Links to mood symptoms and the effect of sleep stabilization

Discussion

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Implication

Key Points

Cite This Study

Unstable sleep and rest-activity rhythms in adolescents at-risk for bipolar disorder: Links to mood symptoms and the effect of sleep stabilization

Discussion

Member takes

Implication

Key Points

Cite This Study

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