A fluorogenic and ultrabright probe for imaging of lipid droplets in live and fixed cells

Guorui Zhao; Guanchang Ji; Dongdong Song; Yarong Ma; Guanzheng Tian; Guizhen Zhang

doi:10.1039/d6ay00188b

January 1, 2026Analytical Methods

A fluorogenic and ultrabright probe for imaging of lipid droplets in live and fixed cells

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Key Points

This research aims to develop a new fluorescent probe to specifically image lipid droplets in both live and fixed cells.
Developed a novel fluorescent probe, TPE-Q, for targeting lipid droplets.
Tested the probe’s effectiveness in live and fixed cell environments.
Assessed interactivity of the probe with lipid droplets under various conditions.
The new probe showed strong fluorescence specific to lipid droplets.
Demonstrated successful imaging in both living and fixed cell systems.
Enabled clearer observation of lipid droplets compared to existing methods.

Implication

Demonstrates a novel fluorescent probe for visualizing lipid droplets in cells, highlighting key cellular functions.

Abstract

Lipid droplets(LDs) play an vital role in energy homeostasis and cellular signaling. Therefore, the visualization of LDs is very important. To this end, a new LD-specific fluorescent probe, TPE-Q, was...

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69aa7066531e4c4a9ff5a258 https://doi.org/10.1039/d6ay00188b

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A fluorogenic and ultrabright probe for imaging of lipid droplets in live and fixed cells

Key Points

Implication

Abstract

Discussion

Cite This Study

A fluorogenic and ultrabright probe for imaging of lipid droplets in live and fixed cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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