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March 6, 2026RSC Medicinal Chemistry2 citations

Extending the architecture of bolaamphiphilic disinfectants: An investigation of octenidine and isooctenidine analogs

DTDanielle TalbotCCCaroline M CaseyEBElise L. Bezold

Key Points

  • Examine the effectiveness of new bolaamphiphilic disinfectants and their analogs against antimicrobial resistance.
  • Synthesize octenidine and isooctenidine analogs.
  • Conduct antimicrobial assays to evaluate effectiveness.
  • Analyze toxicity levels in eukaryotic cells.
  • New analogs demonstrate improved antimicrobial activity.
  • Certain compounds show lower toxicity to eukaryotic cells.
  • Potential to reduce antimicrobial resistance in bacterial strains.

Abstract

Quaternary ammonium compounds (QACs) have been used in commercial disinfectants since the mid-1900s due to their strong antimicrobial activity and relatively low toxicity to eukaryotic cells. However, antimicrobial resistance to...

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Cite This Study

Talbot et al. (2026) studied this question.

synapsesocial.com/papers/69aa7077531e4c4a9ff5a524https://doi.org/10.1039/d5md01098e
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