Key result
Targeting histone methylation enzymes offers therapeutic potential to modulate multi-organ fibrosis.
Why the study?
Histone methylation is increasingly recognized as a key epigenetic regulator of fibrosis initiation and progression, prompting a systematic summary of its mechanisms and therapeutic potential across multiple organs.
Targeting histone methylation modifications and their regulatory enzymes offers a promising epigenetic approach for the treatment of multi-organ fibrotic diseases.
Hypothesis-generating for epigenetic therapies targeting histone methylation in cardiac fibrosis; extends multi-organ evidence and requires dedicated trials before clinical adoption.
Fibrosis is a pathological process characterized by excessive extracellular matrix deposition, leading to tissue stiffening and organ dysfunction, posing a significant threat to human health. In recent years, histone methylation, a key epigenetic modification, has been increasingly recognized for its crucial regulatory role in the initiation and progression of fibrosis. By modulating chromatin structure and gene expression, histone methylation influences the activation of fibrosis-related cells, inflammatory responses, and cellular fate transitions. This review systematically summarizes the molecular mechanisms of histone methylation in fibrosis across multiple organs, including the kidney, liver, heart, and lungs. It emphasizes the functions and regulatory networks of methyltransferases and demethylases, integrating the latest experimental and clinical findings. Furthermore, potential therapeutic strategies targeting histone methylation are discussed, highlighting their promise for precise anti-fibrotic interventions. By consolidating advances in multi-organ fibrosis research, this article aims to provide a theoretical foundation and practical guidance for the future development of targeted fibrosis therapies.
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Tao et al. (2026) conducted a review in Patients with fibrosis affecting multiple organs including kidney, liver, heart, and lungs. This review summarizes the crucial regulatory role of histone methylation in fibrosis across organs including kidney, liver, heart, and lungs and highlights the therapeutic potential of targeting histone methyltransferases and demethylases to modulate fibrotic progression.
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