Longitudinal analysis shows changes in activity patterns relate to brain atrophy in multiple sclerosis, suggesting potential biomarkers for disease monitoring.
Within-person reductions in daytime activity patterns precede clinical disability worsening and brain atrophy in PwMS. Although results require confirmation and thresholds of and responsiveness to change need to be established, longitudinal accelerometry may offer sensitive, noninvasive biomarkers of subclinical disease.
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Fitzgerald et al. (2026) studied this question.
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