Analysis of early biochemical recurrence in patients with positive surgical margins, indicating a need for tailored surveillance strategies.
PSMs are associated with an increased risk of early biochemical recurrence, while early functional outcomes appear independent of margin status. Tumor biology, rather than surgical factors, emerges as the main determinant of margin positivity. These findings support a risk-adapted interpretation of PSMs and align with current guidelines favoring close surveillance and early salvage treatment over routine adjuvant therapy.
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Zambudio-Munuera et al. (2026) studied this question.
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