Key result
A contralateral positive surgical margin to the dominant tumor was associated with a significantly worse biochemical recurrence prognosis compared to a same-side margin in high-risk prostate cancer.
Why the study?
Positive surgical margin after radical prostatectomy associates with biochemical recurrence, and the study aimed to evaluate the clinical significance of margin laterality and its correlation with dominant tumor.
Does positive surgical margin (PSM) laterality and dominant tumor laterality affect biochemical recurrence-free survival in patients with localized prostate cancer after radical prostatectomy?
Observational (n=406)
No
Does positive surgical margin (PSM) laterality and dominant tumor laterality affect biochemical recurrence-free survival in patients with localized prostate cancer after radical prostatectomy?
This is the authors' abstract. We don't add key points for this paper.
Positive surgical margin (PSM) after radical prostatectomy (RP) is an established factor associated with the outcome of biochemical recurrence (BCR). Dominant tumor is presumed to harbor the most aggressive biological behavior. The aim of this study was to evaluate the clinical significance of the PSM laterality and its correlation with dominant tumor.
While overall tumor and margin laterality do not significantly impact prognosis, a contralateral positive surgical margin to the dominant tumor in high-risk prostate cancer is associated with worse biochemical recurrence, suggesting more aggressive invasive behavior.
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Wu et al. (2022) conducted an observational in Prostate cancer with positive surgical margin (n=406). Contralateral positive surgical margin to dominant tumor vs. Same side positive surgical margin to dominant tumor was evaluated on Biochemical recurrence (BCR) in high-risk cases (Gleason score ≥ 4+3) (p=<0.001). A contralateral positive surgical margin to the dominant tumor was associated with a significantly worse biochemical recurrence prognosis compared to a same-side margin in high-risk prostate cancer.
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