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January 1, 2026Open Access

Circ-Eif3c Carried by M2 Macrophage-Derived Exosomes Mitigates Asthma Progression via miR-15a-5p/GSS/SOCS6 Axis Inhibition.

Jiaying Yuan Jiayi Zhao Xiahui Ge Xingxing Zhu Li Li Haoran Ni Jian Fan Yi Zhang Yahong Sun Yan Shang

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Key Points

The aim is to explore the role of circ-Eif3c-enriched exosomes in mitigating asthma progression.
Analyzed the effects of M2 macrophage-derived exosomes on airway epithelial cells (AECs)
Assessed the function of miR-15a-5p, GSS, and SOCS6 in airway remodeling
Circ-Eif3c-enriched exosomes significantly improved AEC function
Exosome treatment led to reduced airway remodeling

Implication

Investigating how exosomes from M2 macrophages reduce asthma progression, suggesting beneficial therapeutic implications.

Abstract

In conclusion, circ-Eif3c-enriched M2Φ-Exos attenuated airway remodeling by restoring the function of AECs.

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69abc0b85af8044f7a4e96ff https://doi.org/10.1155/mi/8350424

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