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March 26, 2026AutoimmunityOpen Access

Molecular mechanism of Mir-27B-3P carried by bronchial epithelial cell-derived extracellular vesicle in airway inflammation in asthmatic mice

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Authors

NDNiu DingCentral South UniversitySXSiran XuChina Three Gorges UniversityYCYanping ChenHunan Children's Hospital

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Overview

Demonstrates the mechanism of bronchial epithelial cell-derived extracellular vesicles in airway inflammation, highlighting potential therapeutic targets in asthma.

Key Points

  • This research investigates how miR-27b-3p carried by extracellular vesicles affects airway inflammation in asthmatic mice.
  • Isolated bronchial epithelial cell-derived extracellular vesicles from asthma mouse models.
  • Established asthma models using ovalbumin and analyzed neutrophils.
  • Measured levels of proinflammatory factors using ELISA and assessed dsDNA levels.
  • Performed RT-qPCR and Western blot to detect gene and protein expression in lung tissues.
  • Validated the miR-27b-3p/ZMAT3/FGF1 signaling pathway through combined experiments.
  • Findings showed increased airway inflammation and NET formation in mice treated with BEC-EVs.
  • BEC-EVs elevated miR-27b-3p levels in neutrophils while inhibiting ZMAT3 and promoting FGF1 expression.
  • ZMAT3 overexpression or FGF1 knockdown mitigated BEC-EVs-induced inflammation effects.

Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc69fdc3bde4489179f2https://doi.org/10.1080/08916934.2026.2644140
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