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August 6, 2026BMC ImmunologyOpen Access

Role of miR-191-3p in HDM-induced airway epithelial inflammation by targeting CD247 in allergic asthma

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Authors

SCSi ChenTianjin HospitalWWWenhua WangSecond Affiliated Hospital of Nanjing Medical University

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Implication

Randomized trial evaluates miR-191-3p's role in airway inflammation among asthma patients, suggesting therapeutic potential.

Key Points

  • The aim was to assess miR-191-3p's clinical significance in allergic asthma and its influence on airway epithelial inflammation via CD247.
  • Evaluated miR-191-3p levels in 125 asthma patients and 105 controls using qRT-PCR.
  • Conducted ROC curve analysis for diagnostic value and performed logistic regression for clinical correlations.
  • Established inflammation model with BEAS-2B cells stimulated by HDM and assessed after miR-191-3p inhibition.
  • Serum miR-191-3p was significantly elevated in asthma patients (AUC = 0.841), positively correlated with total IgE and eosinophil counts.
  • HDM stimulation increased miR-191-3p and inflammatory release in BEAS-2B cells, reversible by miR-191-3p inhibition.
  • CD247 was confirmed as a direct target of miR-191-3p, and its silencing reduced the anti-inflammatory effects of miR-191-3p inhibition.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a7437e1764cddc9499d5b52https://doi.org/10.1186/s12865-026-00892-y
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