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July 5, 2026Journal of Asthma

Clinical significance and effects of miR-431-5p in children with asthma

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Authors

YHYafei HouLJLuping JiJGJielin Gao

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Overview

Randomized trial investigates miR-431-5p effects on asthma in children, suggesting diagnostic potential for biomarkers.

Key Points

  • This study aims to evaluate the role of miR-431-5p in childhood asthma and its cellular effects in response to allergens.
  • Differential miRNA expression analyzed using bioinformatics tools on GSE263408 dataset.
  • Serum levels of miR-431-5p and CD34 mRNA were measured in asthmatic versus healthy children.
  • In vitro experiments with human airway smooth muscle cells (ASMCs) and mast cells treated with house dust mite (HDM) to assess molecular effects.
  • Serum miR-431-5p was downregulated in asthmatic children compared to healthy children (AUC = 0.866 for diagnostics).
  • Levels of miR-431-5p further decreased in children with asthma recurrence/exacerbation (AUC = 0.787).
  • miR-431-5p reduced CD34 mRNA and affected viability and degranulation processes in HDM-induced cell models.

Cite This Study

Hou et al. (2026) studied this question.

synapsesocial.com/papers/6a49f7b5f5d1d45b288014dchttps://doi.org/10.1080/02770903.2026.2696584
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