Cortisol assays across the physiologic spectrum: Access immunoassay compared with LC-MS/MS

Andrew J Newman; Sanan Mahrokhian; Isabelle Hanna; Tsai Cl; Stefanie Parisien-La Salle; Jenifer M. Brown; David G. Stouffer; Richard Auchus; Anand Vaidya

doi:10.1093/ejendo/lvag043

March 4, 2026European Journal of Endocrinology

Cortisol assays across the physiologic spectrum: Access immunoassay compared with LC-MS/MS

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Key Points

To compare the accuracy of cortisol measurements between immunoassays and LC-MS/MS methods.
Analyzed cortisol levels using both immunoassay and LC-MS/MS techniques.
Evaluated measurement consistency across different physiological states.
Immunoassay results aligned closely with LC-MS/MS measurements.
Both methods yielded reliable cortisol assessments across the physiologic spectrum.

Implication

Clinicians compare cortisol measurements from immunoassays and LC-MS/MS across various physiological conditions, indicating reliability of both methods.

Abstract

Clinicians should be reassured that this immunoassay provides cortisol measurements similar to gold-standard LC-MS/MS across the physiologic continuum.

Discussion

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Cite This Study

Newman et al. (2026) studied this question.

synapsesocial.com/papers/69abc1535af8044f7a4e9dd5 https://doi.org/10.1093/ejendo/lvag043

View Full Paper

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Cortisol assays across the physiologic spectrum: Access immunoassay compared with LC-MS/MS

Key Points

Implication

Abstract

Discussion

Cite This Study

Cortisol assays across the physiologic spectrum: Access immunoassay compared with LC-MS/MS

Key Points

Implication

Abstract

Discussion

Cite This Study

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