Synthesis of ( R )‐Rasagiline and its Analogues via Chemo‐ and Enantioselective Hydrosilylation of N ‐Propargyl‐indan‐1‐imines

By using a rigid chiral picolinamide Lewis base catalyst prepared from commercially available and cost‐effective chloramphenicol base, chemo‐ and enantioselective hydrosilylation of N ‐propargyl‐indan‐1‐imines has been realized. This transformation allowed the synthesis of various enantioenriched N ‐propargyl‐1‐indanamines including ( R )‐rasagiline with moderate to good yields (up to 99%) in low to good enantioselectivities, typically ranging 18%–75% ee and in one case up to 99% ee.