Demonstrates that neuropilin-2 deficiency triggers retinal degeneration via mitochondrial dysfunction, suggesting a potential treatment pathway.
NRP2 is a critical regulator of mitochondrial integrity and NAD⁺ metabolism in the RPE. Its loss disrupts metabolic homeostasis, promoting RPE senescence and retinal degeneration. Targeting the NRP2-mitochondria-NAD⁺ axis with echinacoside represents a promising therapeutic strategy for preventing retinal degenerative diseases.
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Ou et al. (2026) studied this question.
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