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January 1, 2026Psychological MedicineOpen Access

Dynamic coactivation patterns during repetitive negative thinking: A cross-sectional fMRI study

Marvin Sören Meiering Emily L. Belleau David Weigner Rebecca Gruzman D. A. Pizzagalli Sören Enge S. Grimm

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Key Points

The study aims to explore how brain network activations relate to repetitive negative thinking (RNT) in individuals with high neuroticism.
Conducted a cross-sectional fMRI analysis
Examined brain activation patterns during resting and task states
Identified and compared coactivation patterns (CAPs)
Individuals with high neuroticism showed more time in salience and default mode networks (DMN) CAPs
Less segregated CAPs were linked to higher vulnerability to RNT
Concurrent activation of functionally antagonistic networks (FPN + DMN) emerged in those prone to RNT

Implication

Cross-sectional fMRI study reveals adaptive brain network configurations linked to repetitive negative thinking.

Discussion

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Cite This Study

Meiering et al. (2026) studied this question.

synapsesocial.com/papers/69abc2075af8044f7a4eb40f https://doi.org/10.1017/s0033291726103572

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