What question did this study set out to answer?

This research aims to explore how lymphangiogenesis influences T cell activation and responses in diffuse large B-cell lymphoma (DLBCL).

March 7, 2026Cancer Immunology Research

Abstract LB-B003: Exploiting lymphangiogenesis to boost anti-tumor T cell responses in B cell lymphoma

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This research aims to explore how lymphangiogenesis influences T cell activation and responses in diffuse large B-cell lymphoma (DLBCL).
Analyzed gene expression data from the NCICCR-DLBCL database to correlate VEGF-C expression with prognosis.
Developed an in vivo vaccination model using VEGF-C-expressing cells combined with lymphoma antigens.
Combined VC Vax with aCD19 CAR T cells to evaluate T cell functions at the vaccination site and systemically.
Conducted flow cytometry and restimulation assays to assess T cell activation and proliferation.
High levels of VEGF-C correlated with improved prognosis and greater tumor-infiltrating lymphocyte signatures in DLBCL.
CAR T-cells accumulated preferentially at the vaccination site, enhancing dendritic cell recruitment and local T cell activation.
VC Vax increased granzyme B expression in circulating T cells, suggesting differentiation of systemic effector functions.
Vaccinated mice demonstrated protection against primary tumor challenges and sustained immunity against subsequent lymphoma rechallenges.

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Implication

Combination approaches enhance anti-tumor T cell responses in B cell lymphoma, suggesting a novel strategy for improving CAR T-cell therapy effectiveness.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69abc2555af8044f7a4ebca3 https://doi.org/10.1158/2326-6074.io2026-lb-b003

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Implication

Combination approaches enhance anti-tumor T cell responses in B cell lymphoma, suggesting a novel strategy for improving CAR T-cell therapy effectiveness.

Abstract LB-B003: Exploiting lymphangiogenesis to boost anti-tumor T cell responses in B cell lymphoma

Key Points

Discussion

Implication

Cite This Study

Abstract LB-B003: Exploiting lymphangiogenesis to boost anti-tumor T cell responses in B cell lymphoma

Key Points

Discussion

Implication

Cite This Study

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