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June 26, 2026Blood Cancer Discovery

Abstract IA005: Analysis of site-specific CAR T cell efficacy in LBCL and development of novel engineering strategies

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Authors

GSGillian SavageZMZachary MorsePLPauline Loos

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Overview

Randomized trial analyzes CAR T cell behavior in LBCL locations, suggesting new strategies for improved effectiveness.

Key Points

  • This study investigates how CAR T cells perform in different anatomical sites of large B cell lymphomas.
  • Reviewed data from a CD19 CAR T-cell clinical trial focusing on response rates by disease presentation.
  • Used an immunocompetent mouse model to study CAR T cell engraftment and B cell clearance across various sites.
  • Conducted a CRISPR knockout screen to identify factors enhancing CAR T cell efficacy at relapse-prone sites.
  • Liver exhibited poor tumor clearance, with frequent CAR T cell relapse observed.
  • CAR T cells in the liver showed impaired activity and increased inhibitory receptors (CD39, TIM-3).
  • Identified strategies to improve CAR T cell function in both site-specific and tissue-agnostic contexts.

Cite This Study

Savage et al. (2026) studied this question.

synapsesocial.com/papers/6a3e1a3d030ad1a9b3092ca1https://doi.org/10.1158/2643-3249.lymphoma26-ia005
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