Age-Specific Association Between Urinary Phthalate Metabolites and Diabetes Mellitus: Findings from the Korean National Environmental Health Survey Cycle 4 (2018–2020)
Cross-sectional analysis reveals age-specific associations between urinary phthalate metabolites and diabetes mellitus, suggesting tailored interventions are needed.
Key Points
This research investigates how urinary phthalate metabolites associate with diabetes mellitus across different age groups.
Conducted a cross-sectional analysis using data from the Korean National Environmental Health Survey Cycle 4 (2018–2020).
Included adults aged 19 years and older with complete data and analyzed eight urinary metabolites.
Applied complex survey-weighted logistic regression to estimate odds ratios for diabetes mellitus, adjusting for various factors and stratifying by age group.
Geometric mean concentrations of metabolites in participants with diabetes mellitus varied significantly by age.
Statistically significant interactions for selected metabolites like MnBP, MCPP, and MEP were identified.
Stratified analyses showed stronger associations for MnBP and MCPP in young adults, while MEP was more strongly associated with older adults.