Experimental findings reveal low-dose caffeine enhances morphine analgesia in mice, suggesting implications for pain management.
A low dose of caffeine synergistically enhanced morphine-induced analgesia in the mouse hot-plate test; this effect was absent at a higher dose. Consequently, only low-dose caffeine administration effectively reduced the required dosage of morphine for acute pain management in the mouse hot-plate test.
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Ebrahimi-Ghiri et al. (2025) studied this question.
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