Why the study?
Does low-dose morphine reduce pain perception and blood pressure responses during the cold pressor test in healthy adults?
Does low-dose morphine reduce pain perception and blood pressure responses during the cold pressor test in healthy adults?
Low-dose morphine attenuates pain and blood pressure responses to cold pressor testing in healthy adults without altering muscle sympathetic outflow.
May guide low-dose opioid strategies for acute pain with hemodynamic monitoring; extends mechanistic evidence on morphine's selective cardiovascular effects.
In this randomized, crossover, placebo-controlled trial, we found that low-dose morphine administration reduced pain perception and blood pressure responses during the cold pressor test via attenuated increases in heart rate and cardiac output. We also determined that muscle sympathetic outflow responses during the cold pressor test seem to be unaffected by low-dose morphine administration. Finally, our exploratory analysis suggests that biological sex does not influence morphine-induced antinociception in healthy adults.
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Watso et al. (2022) studied this question.
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