Key result
Low-dose morphine reduced tolerance to simulated hemorrhage compared to placebo in healthy adults, without affecting muscle sympathetic outflow.
Why the study?
Does low-dose morphine reduce tolerance to simulated hemorrhage in healthy adults?
RCT
crossover
Does low-dose morphine reduce tolerance to simulated hemorrhage in healthy adults?
Low-dose morphine reduces tolerance to simulated hemorrhage in healthy adults, suggesting it may not be an ideal analgesic for hemorrhaging patients in the prehospital setting.
May warrant avoiding low-dose morphine in prehospital hemorrhage; challenges hemodynamic safety assumptions and extends RCT evidence on opioids.
In this randomized, crossover, placebo-controlled trial, we found that tolerance to simulated hemorrhage was lower after low-dose morphine administration. Such reductions in hemorrhagic tolerance were observed without differences in MSNA burst frequency responses between morphine and placebo trials. These data, the first to be obtained in conscious humans, demonstrate that low-dose morphine reduces hemorrhagic tolerance. Thus, morphine is not an ideal analgesic for a hemorrhaging individual in the prehospital setting.
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Watso et al. (2022) conducted an RCT in healthy adults. Low-dose morphine vs. Placebo was evaluated on tolerance to simulated hemorrhage. Low-dose morphine reduced tolerance to simulated hemorrhage compared to placebo in healthy adults, without affecting muscle sympathetic outflow.
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