Findings reveal basophils enhance tissue regeneration in skin via macrophage polarization, suggesting new targets for chronic wound therapy.
Our study uncovers a novel pro-repair function of basophils in sensitizer-exposed skin. Beyond their well-known role in provoking itch and inflammation, basophils are critical for initiating type 2 immune-mediated tissue regeneration via IL-4/IL-13-dependent macrophage reprogramming. This axis represents a promising therapeutic target for chronic wounds, particularly in the context of allergic skin disorders.
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Zhang et al. (2026) studied this question.
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