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March 8, 2026Behaviour Research and TherapyOpen Access

Exploring Mediators and Moderators in the Relationship Between Anxiety and Alcohol Use: A Systematic Review

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Authors

TGTara GückelKPKatrina PriorNNNicola C. Newton

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Overview

Systematic review identifies mediators and moderators affecting alcohol use in individuals with anxiety, suggesting further research is needed.

Key Points

  • This review aims to synthesize mediators and moderators in the relationship between anxiety and alcohol use.
  • Conducted a systematic review of longitudinal studies
  • Assessed risk of bias using two quality assessment tools
  • Extracted effects from 315 unique models concerning mediation and moderation
  • Identified 55 eligible studies from 14,776 records
  • Significant moderators included age, externalising factors, perceptions of peer alcohol use, positive family experiences, and experimental manipulation of anxiety
  • No consistent evidence for mediating mechanisms in either anxiety to alcohol or alcohol to anxiety pathways

Cite This Study

Gückel et al. (2026) studied this question.

synapsesocial.com/papers/69acc5b032b0ef16a4050339https://doi.org/10.1016/j.brat.2026.105006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bias in cross-sectional analyses of longitudinal mediation.2007 · 3,220 citations
  2. 2Gender Differences in the Epidemiology of Alcohol Use and Related Harms in the United States2020 · 758 citations
  3. 3The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications1997 · 3,226 citations
  4. 4Daily Relationship Between Event-Specific Drinking Norms and Alcohol Use: A Four-Year Longitudinal Study2011 · 56 citations
  5. 5The relationship between adverse childhood experiences, family functioning, and mental health problems among children and adolescents: a systematic review2019 · 192 citations