Findings reveal impaired spermatogenesis in mouse testis, indicating obstructive azoospermia is affected by chronic stress.
The present results suggest that chronic obstructive stress, driven by mechanical stress and/or local ischemia, is dominant in the caudal region and near the rete testis of the mouse testis. This study established a crucial link between obstructive azoospermia and a pathology resembling non-obstructive azoospermia, underscoring the importance of evaluating such spatial vulnerability in the clinical management of obstructive male infertility.
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Nakata et al. (2026) studied this question.
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