What question did this study set out to answer?

The study aims to explore the effects of continuous and discontinuous scrotal hyperthermia on testicular health and spermatogenesis in a rat model of azoospermia.

June 19, 2026Folia Medica IndonesianaOpen Access

HISTOPATHOlOGICAL EVIDENCE OF IRREVERSIBLE TESTICULAR INJURY AND SPERMATOGENESIS DISRUPTION IN A CONTINUOUS SCROTAL HYPERTHERMIA- INDUCED AZOOSPERMIA RAT MODEL

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Authors

ABAgeng BrahmadhiMuhammadiyah University Purwokerto NANorina AgatriMuhammadiyah University Purwokerto AMAndi Muh. MaulanaMuhammadiyah University Purwokerto

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Implication

Randomized trial shows testicular injury and azoospermia in rats with continuous and discontinuous hyperthermia, indicating different impacts on recovery.

Key Points

The study aims to explore the effects of continuous and discontinuous scrotal hyperthermia on testicular health and spermatogenesis in a rat model of azoospermia.
30 adult male Rattus norvegicus were randomly assigned to control, discontinuous, and continuous hyperthermia groups.
Scrotal hyperthermia was induced by immersing the scrotum in a 45°C water bath for 20 minutes daily over 22 days.
Sperm parameters, testicular weight, and histopathological changes were assessed throughout the experiment.
Continuous hyperthermia led to complete azoospermia by day 22 with irreversible testicular degeneration.
Discontinuous hyperthermia resulted in partial histological recovery by day 37 with improved Johnsen scores compared to the continuous group.
Both hyperthermia methods significantly reduced testicular weight and impaired sperm concentration, motility, and morphology compared to controls.

Cite This Study

Brahmadhi et al. (2026) studied this question.

synapsesocial.com/papers/6a34dd4965a5b0777af2d241 https://doi.org/10.65346/2599-056x.2425

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Implication

Randomized trial shows testicular injury and azoospermia in rats with continuous and discontinuous hyperthermia, indicating different impacts on recovery.

HISTOPATHOlOGICAL EVIDENCE OF IRREVERSIBLE TESTICULAR INJURY AND SPERMATOGENESIS DISRUPTION IN A CONTINUOUS SCROTAL HYPERTHERMIA- INDUCED AZOOSPERMIA RAT MODEL

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Cite This Study

HISTOPATHOlOGICAL EVIDENCE OF IRREVERSIBLE TESTICULAR INJURY AND SPERMATOGENESIS DISRUPTION IN A CONTINUOUS SCROTAL HYPERTHERMIA- INDUCED AZOOSPERMIA RAT MODEL

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