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May 14, 2026Reproductive Medicine and BiologyOpen Access

Reversibility of Spermatogonial Stem Cell Injury After Single Acute Scrotal Hyperthermia in Mouse and Rat Models: A Systematic Review

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Authors

RARashid A. AldahhanImam Abdulrahman Bin Faisal University

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Implication

Systematic review evaluates spermatogonial stem cell recovery after acute scrotal hyperthermia, indicating incomplete recovery implications.

Key Points

  • The review investigates the impact of acute scrotal hyperthermia on spermatogonial stem cells in mice and rats over a full spermatogenic cycle.
  • Systematic review of 18 studies in mouse and rat models using single scrotal heating exposure.
  • Outcomes categorized across structural, cellular, endocrine/apoptotic, and sperm domains.
  • Assessment of injury patterns graded by temperature and species.
  • At 43°C, structural abnormalities persisted longer, with notable loss of SSC and germ cells in mice.
  • Increased tubular apoptosis was consistently observed in mice, while testosterone responses varied across studies.
  • Sperm quality metrics, including motility and DNA integrity, were often impaired at 43°C.

Cite This Study

Rashid A. Aldahhan (2026) studied this question.

synapsesocial.com/papers/6a0566fba550a87e60a1ef90https://doi.org/10.1002/rmb2.70055
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Also Consider

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