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Observations reveal blue toe syndrome in polycythemia vera patients, indicating risks from unstable aortic plaques.
Current guidelines do not adequately address the complexities involved in managing patients with atherosclerotic disease and hematologic prothrombotic comorbidities. Research on antiplatelet therapy and direct oral anticoagulation for treating distal embolization from unstable aortic plaques is needed.
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Chebrolu et al. (2026) studied this question.
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