Experimental evidence reveals target-controlled infusion achieves smoother autonomic modulation during propofol induction, indicating better stability for patients.
TCI provided smoother autonomic modulation than did MB during the physiologically unstable induction phase. By enabling real-time detection of short-lived fluctuations, WBSA revealed mechanistic differences not captured by conventional analyses, supporting TCI as a potentially more stable and physiologically balanced induction strategy, particularly for patients at risk of peri-induction instability.
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Jt et al. (2026) studied this question.
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