Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 8, 2026SHILAP Revista de lepidopterologíaOpen Access

AI-assisted systems pharmacology with experimental validation reveal multi-target anticancer mechanisms of Ganoderma lucidum extracts against lung cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

HWHao WangLCLeilei ChenSZSiqi Zhang

Discussion

Loading...

Member takes

Overview

Systems pharmacology demonstrates multi-target anticancer effects of Ganoderma lucidum extracts in lung cancer, suggesting novel therapeutic strategies.

Key Points

  • This research aims to uncover the multitarget anticancer mechanisms of Ganoderma lucidum extracts against lung cancer.
  • Employed a systems pharmacology approach integrating network analysis and artificial intelligence.
  • Constructed a compound-target-pathway network using bioactive metabolites and lung cancer-associated genes.
  • Validated key interactions through AI-based molecular docking.
  • Functionally tested top multitarget compounds in H1299 nonsmall cell lung cancer cells via viability, migration, and Western blot assays.
  • Identified a network of 67 synergistic targets, including PIK3CA, STAT3, EGFR, and TP53.
  • Demonstrated that G. lucidum extracts inhibit cell proliferation (IC50 = 1669 μg/mL) and suppress cancer cell migration.
  • Reduced phosphorylation of STAT3 and expression of c-Myc in lung cancer cells.
  • Highlighted pivotal roles of triterpenoids like lucidumol A and ganoderic acid A in modulating oncogenic signaling.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69ada836bc08abd80d5bb4cfhttps://doi.org/10.1080/21501203.2026.2634522
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the anti-lung cancer mechanism of <i>Ganoderma lucidum</i> and its relationship with the level of immune cell infiltration based on network pharmacology and molecular docking2024 · 3 citations
  2. 2Potential Active Compounds of <i>Ganoderma lucidum</i> and Their Anticancer Effects: A Comprehensive Review2025 · 8 citations
  3. 3Recent advances in Ganoderma lucidum-derived bioactive components for cancer therapy2026
  4. 4Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation2025
  5. 5Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer2024 · 39 citations