What question did this study set out to answer?

The aim is to explore Ganoderma lucidum polysaccharides' inhibitory effects on cancer and their immune-modulating properties.

The dual role of Ganoderma lucidum polysaccharides in cancer treatment: Meridian tropism-based direct inhibition and immune-mediated modulation

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Review integrates meridian tropism with direct tumor inhibition and immune modulation in cancer therapies.

The aim is to explore Ganoderma lucidum polysaccharides' inhibitory effects on cancer and their immune-modulating properties.
Examined the direct tumor-suppressive effects of G. lucidum polysaccharides for various cancers.
Linked organ-specific anticancer activity with classical meridian tropism in TCM.
Discussed mechanisms such as apoptosis induction and macrophage reprogramming related to immune responses.
GLPs showed effective tumor suppression across lung, liver, and hematological cancers with documented mechanisms.
Highlighted the role of GLPs in enhancing the effects of cancer immunotherapy via immune modulation.
Demonstrated potential synergistic effects of GLPs with immune checkpoint blockers.

Phan et al. (2026) studied this question.

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